British Air Force Typhoon FGR4s have joined forces with French warplanes in a combined operation targeting an hidden munitions depot in Syrian territory used by the IS group, according to the UK Ministry of Defence.
The facility, pinpointed through reconnaissance, was believed to be storing arms and explosives, the release indicated, and was positioned in mountains just north of Palmyra in Syria's central region.
"Our fighter planes utilized Paveway IV guided bombs to hit a number of entry passages leading to the facility... initial indications suggest the objective was successfully hit," the MoD said.
There was no sign of any harm to civilians in the strike late on Saturday and each participating jet returned to base without incident, the ministry further stated.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as the so-called Islamic State - enforced extremist governance over significant areas in Syria and Iraq until 2019.
"This strike shows British leadership, and commitment to work closely with allied nations, to eradicate any re-emergence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary the minister said.
UK warplanes have carried out surveillance missions over Syria to "deter any efforts to regroup" of the group subsequent to its routing at the battle of Baghuz in 2019, the MoD reported.
"I must thank the personnel of British forces participating in this strike for their skill and their courage," the Defence Secretary said. "They were part of thousands of UK service members on duty over the holidays. This action, to take out militants who threaten our security, shows how our armed forces are ready to step up, all year round, ensuring Britain's security domestically and influential overseas."
During December, the American forces carried out what it described as a "large-scale strike" on Islamic State objectives in Syria, following an assault claimed the lives of two US servicemembers and a civilian linguist in the Palmyra area.
The U.N. says Daesh still boasts between 5,000 and 7,000 fighters in Syria and Iraq.